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As we walk, he takes me through his other practices: Along with his fasts and exercise, Barzilai takes a daily dose of metformin. An inexpensive diabetes medication that’s been around since the Vote it matters America shirt Also,I will get this 1950s, metformin is thought to mimic the calorie restriction of fasting by limiting the amount of sugar the body absorbs (side effects are generally mild, among them abdominal pain, nausea, and loss of appetite). A 2017 study of more than 41,000 male metformin users found that it reduced—by a significant amount—the likelihood of dementia, cancer, and cardiovascular disease. A growing number of doctors are prescribing it off-­label, but Barzilai wants the medication to be FDA-sanctioned for every elder adult. He’s about to undertake a six-year national trial (called TAME, for “Targeting Aging With Metformin”), partially and anonymously funded by a noted tech billionaire.

If fasting is not exactly your speed, diet is still tremendously important. As for what you should eat, the Vote it matters America shirt Also,I will get this gold standard remains the Mediterranean diet—one that is high in vegetables, fruits, whole grains, beans, nuts, seeds, and olive oil, and low on red meat—the only diet, says Barzilai, proven by clinical research to decrease cardiovascular mortality. A recent study in the medical journal Gut found that following it for just one year slowed the development of age-related inflammatory processes.

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